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Areas of Research :


Comparative neurobiology of the cerebellum:

        -Evolution of neuronal circuits of the cerebellum and their roles in motor control and coordination of behaviour.

         -Biophysical properties of ionic channels in the membrane of Purkinje cell and other cerebellar neurons and their roles in Information processing in the cerebellar neuronal network.

        -Influences of genetic control and environmental experience on the development of neuronal circuits in the cerebellum.

        -organization of cerebellar afferent and efferent fiber systems and their topographic representations in relation to their functional mechanisms.

        -New functional involvement of the cerebellum.

Pineal gland and melatonin.

        -Neurochemical transmitter and neuropeptide receptor systems in the pineal gland; their co-existence and co-localization, and their roles ion the regulation of the synthesis and release of melatonin hormone from the pineal gland.

        -the role of the pineal gland and melatonin in the generation of circadian rhythms.

        -novel sources of afferent systems from the brain in the regulation of pineal functions.

        -the neuroprotective effects of melatonin

        -the effect of melatonin neural stem cell proliferation and differentiation

Neuronal Transplantation.

     -Development of animal models for neuronal transplantation in the cerebellum, the caudate nucleus and the midbrain reticular formation.

     -Experimental neuronal transplantation for the treatment of Parkinson’s disease, and Alzheimer Dementia.

Early gene expression in the brain.

     -Benzodiazepine receptor gene expression modulation by stress, steroids, and tranquilizers.

     -Developmental changes in gene expression of GABA receptor subunits in the cerebellum.

     -Effects of early experience, handling and rearing on the expression of genes for receptors of glucocorticoid, and serotonin.

     -Effect of CNS stimulants and drugs of potential abuse on the expression of c-FOS and early gene expression in the nucleus accumbens and other regions of the brain.

Behavioural neurobiology of farm animals.

     -Neural control of food intake and feeding behaviour in farm animals.

     -effects of intracerebro-ventricular injection of peptides and hormones on feeding behaviour in farm animals.

     -neuronal plasticity to food and water in the hypothalamus and zona incerta of sheep.

     -development of experimental animal models from farm animals.

Neurotoxicology and neuropathology.

     -Neurotoxicology of volatile substances, organophosphates insecticides, lead and aluminum.

     -Neurotoxins: snake venum and plant and marine neurotoxins.

     -Rabies virus induced alteration of muscarinic receptor affinities and their relationships to the clinical symptoms of rabies.

     -Retrograde and anterograde transneuronal transports of various viruses and the use of viruses as transneuronal tracers.

    -Development of novel neuro-immuno modulators.

Drug and substance abuses.

     -Dependence and tolerance to opiates and other drugs of abuse.

     -Neural pathways and mechanisms of drug dependence and tolerance.

     -Identification of opiate receptors and gene expression.

     -Effects of psychoactive drugs on the neurotransmitter systems related to the reward mechanism.

     -Alteration of immune functions by heroin addiction, tolerance and withdrawal.

     -Amphetamine Abuse and Parkinsonism

Nutritional neuroscience.

     -Nutrients and foods which modify or influence brain functions.

     -Effects of essence of chicken on brain functions.

     -Effects of nutrition on brain development and functions.

Brain tumors.

     -p53 mutations in human astrocytomas

     -Comparison of childhood and adult gliomas by immunohistochistry for the detection of p53 gene expression.

Aging, dementia and Alzheimer disease.

     -Epidemiology of senile dementia and Alzheimer disease in Thailand.

     -Topographic brain mapping of normal aging , senile dementia and Alzheimer disease.

     -The distribution of iso-forms of Apolipoprotein E in the Thai population and the relationship to senile dementia of Alzheimer type.

     -Cacium binding proteins in aging and senile dementia of Alzheimer type.

     -Alteration of neurotransmitter systems, growth and neurotrophic factors in aging, senile dementia and Alzheimer disease.

     -The role of stress and adrenocortical hormones in aging and senile dementia.

Sleep disorders and Sudden Unexplained Nocturnal Death Syndrome (SUNDS).

         -Epidemiology and distribution of sleep disorders in Thailand.

         -Pathophysiology of sleep apnea syndromes.

         -Epidemiology and pathophysiology of SUNDS.

         -Genetic linkage and molecular biological studies of SUNDS.

         -Neuropsychiatric disorders

         -Alteration of serotonin receptors in schizophrenia  

Neural Stem cells

         -Neural stems cells for neurological therapy of stroke, (cerebro vasular diseases), Parkinson’s disease, spinal cord injuries

         -Effect of A-beta on adult sub ventricular zone neurogenesis  through p75 neurotrophin  receptors